Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIVArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Analysis Antibody Response CD4 CD4 cell CD4 count CD4 T-cell CD4 T-cell counts Cluster Complete COVID-19 vaccine COVID-19 vaccines determine dose evaluated Humoral response IgG IgG antibody immunization Immunosuppression impair individual log median mRNA multicentre neutralization Neutralizing antibodies Patient people living with HIV PLWH predictor Probability prospective cohort study quantitative determination receiving response to vaccination SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion Specific the antibody response the vaccine vaccination Vaccine vaccine. with HIV [DOI] 10.1016/j.cmi.2022.05.018 PMC 바로가기
Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interactionArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting-enzyme-2 binding binding interaction blocking virus entry Brown caused characterized coronavirus demonstrated disease ELISA enzyme-linked immunosorbent evaluate evaluated feasible global pandemic immunization immunized Immunoglobulin immunoglobulin Y in vitro Infection inhibit kDa Laying Laying hens molecular weight Neutralizing nucleocapsid purified RBD RBD-ACE2 Receptor binding domain Receptor-binding-domain SARS-CoV-2 SARS-CoV-2. SDS-PAGE serum Specific spike glycoprotein [DOI] 10.1016/j.intimp.2022.109280 PMC 바로가기
Inflammatory myopathy following coronavirus disease 2019 vaccination: A systematic reviewArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Public Health [Category] 진단, [키워드] accompanied adverse event antibodies article autoantibodies autoantibody BNT162b2 ChAdOx1 Clinical course clinical feature complications composed conducted coronavirus disease coronavirus disease 2019 vaccine COVID-19 COVID-19 vaccination COVID-19 vaccine critical appraisal dermatomyositis Follow-up identify Immune-mediated IMPROVE independent induce Inflammatory inflammatory myopathy investigator Joanna Briggs Institute management muscular myositis myositis specific autoantibodies. occurred Onset Patient patients presenting proportion report reported Risk of bias SARS-CoV-2 SARS-CoV-2 vaccine searched Side effect skin rash Specific subtype Symptom systematic review Treatment vaccination Vaccine vaccine dose weakness were used [DOI] 10.3389/fpubh.2022.1007637 PMC 바로가기
Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritisArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition age anti-CD20 therapy anti-S anti-S antibody anti-SARS-CoV-2 antibodies antibody Antibody Response BNT162b2 cell-mediated response Cellular immune response cellular immune responses ChAdOx1 Concentration Corona covariate adjustment COVID-19 COVID-19 vaccine declined dependent on DMARD (disease-modifying antirheumatic drug treatment) domains dose enrolled Factor healthy controls humoral IL-6 inhibitor immune response Infection inhibited investigated IQR magnitude median time mRNA-1273 Patient patients patients treated peptides positive patient reduced respiratory rheumatoid arthritis RNA RNA vaccine SARS-CoV-2 significant effect significantly Specific specific antibodies specific antibody subject T-cell T-cell Response targeted therapy the healthy the interferon the SARS-CoV-2 the vaccine therapy vaccination vaccination. Vaccine variables was measured were infected [DOI] 10.3389/fimmu.2022.960001 PMC 바로가기
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanismArticle Published on 2022-10-102022-11-15 Journal: Molecular Medicine [Category] 바이오마커, [키워드] Accuracy acute COVID-19 Angiogenesis AUC Biomarker Biomarkers Blood case-control study characterized Cohort COVID-19 Diagnosis diagnostics disease elevated Endoglin female Follow-up Health healthy control ICAM-1 immunoassay Inpatient Intervention investigated lack long-COVID machine machine learning marker median multiplex outpatients pathophysiological mechanism Patient patients Post-infection Sensitivity and specificity Sex significantly Specific subject Symptom targeted therapy therapeutic efficacy unique Vascular Vascular transformation. vasculature VCAM-1 VLA-4 [DOI] 10.1186/s10020-022-00548-8 PMC 바로가기
Molecular and Structural Analysis of Specific Mutations from Saudi Isolates of SARS-CoV-2 RNA-Dependent RNA Polymerase and their Implications on Protein Structure and Drug-Protein BindingArticle Published on 2022-10-012022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Affect approaches binding energy caused collected conformational Coronavirus-2 COVID-19 COVID-19 pandemic develop effort element health system information Interaction isolate molecular Molecular dynamics simulation morbidity and mortality mutant RdRp mutants Mutation mutations mutations. Pandemics Protein protein stability RdRP Remdesivir RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 RdRp sequence SARS-CoV2 Saudi Arabia secondary structure significant level Specific Structure therapeutic variety virus wild type wild-type Wuhan, China [DOI] 10.3390/molecules27196475 PMC 바로가기
Immunogenicity and safety of the booster BNT162b2 vaccine in patients with axial spondyloarthritis treated with biological disease-modifying drugsArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome adverse event antibody concentration axial spondyloarthritis biological disease-modifying drug BNT162b2 BNT162b2 vaccine booster booster doses booster vaccination clinical questionnaire Cohort cohorts comparable coronavirus disease Coronavirus-2 COVID-19 enrolled evaluated Evidence flow cytometric General population healthy control humoral IL-17 immune response Immune-mediated inflammatory disease immunogenicity individuals inhibitor inhibitors intracellular cytokine investigated male no difference outcome Patient patients patients treated peptide-based persistence prospective observational study Responder Safety SARS-CoV-2 Specific spondyloarthritis subgroups T-cell T-cell immune response T-cell Response therapy TNFα treated tumor necrosis factor-alpha vaccination vaccination. virus-neutralizing antibody were assessed [DOI] 10.3389/fimmu.2022.1010808 PMC 바로가기
The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics proteomics. responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기